Ponce De Leon, MO is a city located in Stone County, Missouri and has a land area of 1.06 square miles (2.75 km2). The water area for the city is 0.00 square miles or 0.00 km2. There is one unique zip code in Ponce De Leon, Missouri and it is 65728. The area code(s) for Ponce De Leon is 417.
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